Novel Mouse Model for Studying Hemostatic Function of Human Platelets
WEBJun 4, 2020 · Platelets are critical to the formation of a hemostatic plug and the pathogenesis of atherothrombosis. Preclinical animal models, especially the mouse, provide an important platform to assess the efficacy and safety of antiplatelet drugs.
Improved Human Erythropoiesis and Platelet Formation in Humanized …
WEBOct 11, 2016 · Robust human erythropoiesis up to final nucleated RBC progenitors in vivo. In this article, Rahmig and colleagues report on highly improved reconstitution of human thrombocytes and erythroid cells in a KIT-deficient humanized mouse model, NSGW41 mice.
Novel Mouse Model for Studying Hemostatic Function of Human Platelets
WEBWe establish a novel adoptive transfer approach to replace endogenous mouse platelets with human platelets for in vivo studies in mice. Hemostatic function of human platelets was validated in the absence and presence of antiplatelet drugs, using the saphenous vein laser-induced injury model.
Humanized mouse models for inherited thrombocytopenia studies
WEBOct 17, 2023 · Current situation and EFFECT of platelet humanized mouse models. Perez et al. transplanted MB-HSCs into the NOD-scid mice and successfully established an in vivo model that can produce human MKs and PLTs.
Humanized mouse models for inherited thrombocytopenia studies
WEBHumanized mouse models (HMMs) refer to immunodeficient mice that have been used for the investigation of human hematopoiesis and immunity for years. With engrafted human hematopoietic stem cells (HSCs), the differentiation process of HSCs and re-construction of platelets can be monitored in the mice.
Frontiers | Benefits and limitations of humanized mouse models …
WEBSimilar to erythrocytes, human megakaryocytes are detectable in the bone marrow of humanized mice; however, human platelets are not detectable in the peripheral blood of humanized mice.
Engineering humanized mice for improved hematopoietic …
WEBMar 19, 2012 · Humanized mice are immunodeficient animals engrafted with human hematopoietic stem cells that give rise to various lineages of human blood cells throughout the life of the mouse. This article...
Humanized mice for immune system investigation: progress
WEBOct 12, 2012 · Severely immunodeficient mice engrafted with functional human cells and tissues, known as 'humanized' mice, facilitate progress in studies of human haematopoiesis, immunity, gene therapy,...
Full reconstitution of human platelets in humanized mice after ...
WEBAug 23, 2012 · These data indicate that the mouse hematopoietic microenvironment is capable of supporting human megakaryocyte maturation and platelet biogenesis, and that the poor human platelet reconstitution in humanized mice was mainly because of rejection by mouse macrophages.
Comparison of the central human and mouse platelet signaling …
WEBDec 22, 2020 · This study aims to compare the central platelet signaling network in platelets of mouse and human. For this the platelet protein interaction networks were reconstructed based on a comparative RNAseq dataset .